执行职能
功能(生物学)
神经科学
计算机科学
扣带回前部
机制(生物学)
心理学
任务切换
控制(管理)
认知
工作记忆
弹道
认知心理学
生物
人工智能
物理
量子力学
天文
进化生物学
作者
Zaixu Cui,Jennifer Stiso,Graham L. Baum,Jason Z. Kim,David R. Roalf,Richard F. Betzel,Shi Gu,Zhixin Lu,Cedric Huchuan Xia,Xiaosong He,Rastko Ćirić,Desmond J. Oathes,Tyler M. Moore,Russell T. Shinohara,Kosha Ruparel,Christos Davatzikos,Fabio Pasqualetti,Raquel E. Gur,Ruben C. Gur,Danielle S. Bassett,Theodore D. Satterthwaite
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2020-03-27
卷期号:9
被引量:51
摘要
Executive function develops during adolescence, yet it remains unknown how structural brain networks mature to facilitate activation of the fronto-parietal system, which is critical for executive function. In a sample of 946 human youths (ages 8-23y) who completed diffusion imaging, we capitalized upon recent advances in linear dynamical network control theory to calculate the energetic cost necessary to activate the fronto-parietal system through the control of multiple brain regions given existing structural network topology. We found that the energy required to activate the fronto-parietal system declined with development, and the pattern of regional energetic cost predicts unseen individuals’ brain maturity. Finally, energetic requirements of the cingulate cortex were negatively correlated with executive performance, and partially mediated the development of executive performance with age. Our results reveal a mechanism by which structural networks develop during adolescence to reduce the theoretical energetic costs of transitions to activation states necessary for executive function.
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