抗体依赖性增强
登革热病毒
登革热
病毒学
生物
病毒
抗体
病毒血症
病毒进入
免疫学
病毒复制
作者
Chee-Yong Chan,John Z.H. Low,Esther S. Gan,Eugenia Z. Ong,Summer L. Zhang,Hwee Cheng Tan,Xiaoran Chai,Sujoy Ghosh,Eng Eong Ooi,Kap Luk Chan
出处
期刊:mSphere
[American Society for Microbiology]
日期:2019-10-30
卷期号:4 (5)
被引量:19
标识
DOI:10.1128/msphere.00528-19
摘要
Dengue virus is the most prevalent mosquito-borne viral infection globally, resulting in variable manifestations ranging from asymptomatic viremia to life-threatening shock and multiorgan failure. Previous studies have indicated that the risk of severe dengue in humans can be increased by a specific range of preexisting anti-dengue virus antibody titers, a phenomenon termed antibody-dependent enhancement. There is hence a need to understand how antibodies augment dengue virus infection compared to the alternative canonical receptor-mediated viral entry route. Herein, we show that, besides facilitating viral uptake, antibody-mediated entry increases the expression of early host dependency factors to promote viral infection; these factors include RNA splicing, mitochondrial respiratory chain complexes, vesicle trafficking, and ribosomal genes. These findings will enhance our understanding of how differences in entry pathways can affect host responses and offer opportunities to design therapeutics that can specifically inhibit antibody-dependent enhancement of dengue virus infection.
科研通智能强力驱动
Strongly Powered by AbleSci AI