[Inhibiting the expression of glucose transporter 1 reduces the proliferation, invasion and migration of neuroblastoma cells].

Objective To study the effect of inhibiting the expression of glucose transporter 1 (GLUT1) in neuroblastoma cells on the proliferation, invasion and migration of tumor cells. Methods The specific small molecule inhibitor WZB117 was used to inhibit the expression of GLUT1 in neuroblastoma cells. The expression of GLUT1 mRNA was detected by real-time quantitative PCR; the expression of GLUT1 protein was detected by Western blotting; the ability of cell proliferation was detected by CCK-8 assay; the ability of cell invasion and migration were detected by TranswellTM invasion and migration assay, respectively. Results After treated with WZB117, the expression level of GLUT1 mRNA increased, while the protein expression level decreased in the neuroblastoma cells. Cell proliferation was inhibited, and the ability of cell invasion and migration were reduced. Conclusion Inhibiting the expression of GLUT1 in neuroblastoma cells might attenuate the malignant biological behaviors of tumor cells.