胶粘剂
自愈水凝胶
材料科学
密封剂
生物相容性材料
粘附
生物医学工程
细胞外基质
生物高聚物
甲基丙烯酸酯
组织粘连
聚合物
伤口愈合
纳米技术
外科
复合材料
聚合
高分子化学
化学
图层(电子)
医学
生物化学
作者
Lei Zhou,Cong Dai,Lei Fan,Yuhe Jiang,Can Liu,Zhengnan Zhou,Pengfei Guan,Yu Tian,Jun Xing,Xiaojun Li,Yian Luo,Peng Yu,Chengyun Ning,Guoxin Tan
标识
DOI:10.1002/adfm.202007457
摘要
Abstract Biocompatible hydrogel adhesives with multifunctional properties, including injectability, fast self‐healing, and suitable on‐demand detachment, are highly desired for minimally invasive procedures, but such materials are still lacking. Herein, an injectable self‐healing biocompatible hydrogel adhesive with thermoresponsive reversible adhesion based on two extracellular matrix‐derived biopolymers, gelatin and chondroitin sulfate, is developed to be used as a surgical adhesive for sealing or reconnecting ruptured tissues. The resulting hydrogels present good self‐healing and can be conveniently injected through needles. The strong tissue adhesion at physiological temperatures originates from the Schiff base and hydrogen bonding interactions between the hydrogel and tissue that can be weakened at low temperatures, thereby easily detaching the hydrogel from the tissue in the gelation state. In vivo and ex vivo rat model show that the adhesives can effectively seal bleeding wounds and fluid leakages in the absence of sutures or staples. Specifically, a proof of concept experiment in a damaged rat liver model demonstrates the ability of the adhesives to act as a suitable laparoscopic sealant for laparoscopic surgery. Overall, the adhesive has several advantages, including low cost and ease of production and application that make it an exceptional multifunctional tissue adhesive/sealant, effective in minimally invasive surgical applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI