介孔二氧化硅
化学
体内
体外
癌细胞
细胞毒性
活性氧
细胞凋亡
纳米颗粒
顺铂
螯合作用
生物物理学
癌症研究
纳米技术
癌症
化疗
生物化学
介孔材料
材料科学
生物
有机化学
生物技术
催化作用
遗传学
作者
Yanyan Zhang,Jiadong Lou,Gareth R. Williams,Yuhan Ye,Dandan Ren,Anhua Shi,Junzi Wu,Wenling Chen,Li‐Min Zhu
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2022-06-04
卷期号:14 (6): 1200-1200
被引量:4
标识
DOI:10.3390/pharmaceutics14061200
摘要
In this study, a pH-responsive controlled-release mesoporous silica nanoparticle (MSN) formulation was developed. The MSNs were functionalized with a histidine (His)-tagged targeting peptide (B3int) through an amide bond, and loaded with an anticancer drug (cisplatin (CP)) and a lysosomal destabilization mediator (chloroquine (CQ)). Cu2+ was then used to seal the pores of the MSNs via chelation with the His-tag. The resultant nanoparticles showed pH-responsive drug release, and could effectively target tumor cells via the targeting effect of B3int. The presence of CP and Cu2+ permits reactive oxygen species to be generated inside cells; thus, the chemotherapeutic effect of CP is augmented by chemodynamic therapy. In vitro and in vivo experiments showed that the nanoparticles are able to effectively kill tumor cells. An in vivo cancer model revealed that the nanoparticles increase apoptosis in tumor cells, and thereby diminish the tumor volume. No off-target toxicity was noted. It thus appears that the functionalized MSNs developed in this work have great potential for targeted, synergistic anticancer therapies.
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