A tRF nucleator for Nucleolin in cancer metastasis

In this issue of Molecular Cell, Liu et al., 2022 Liu X. Mei W. Padmanaban V. Alwaseem H. Molina H. Passarelli M.C. Tavora B. Tavazoie S.F. A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs. Mol Cell. 2022; 82: 2604-2617https://doi.org/10.1016/j.molcel.2022.05.008 Abstract Full Text Full Text PDF Scopus (8) Google Scholar report that 5′-tRFCys, a stress-induced transfer RNA-derived RNA fragment (tRF) derived from the 5′ halves of cysteine tRNAs, regulates post-transcriptional gene expression, enabling the survival and lung metastasis formation of breast cancers. In this issue of Molecular Cell, Liu et al., 2022 Liu X. Mei W. Padmanaban V. Alwaseem H. Molina H. Passarelli M.C. Tavora B. Tavazoie S.F. A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs. Mol Cell. 2022; 82: 2604-2617https://doi.org/10.1016/j.molcel.2022.05.008 Abstract Full Text Full Text PDF Scopus (8) Google Scholar report that 5′-tRFCys, a stress-induced transfer RNA-derived RNA fragment (tRF) derived from the 5′ halves of cysteine tRNAs, regulates post-transcriptional gene expression, enabling the survival and lung metastasis formation of breast cancers. A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAsLiu et al.Molecular CellJune 1, 2022In BriefLiu et al. report that a tRNA-derived fragment (5′-tRFCys) is upregulated during breast cancer progression and is required for breast cancer metastatic lung colonization. 5′-tRFCys binds to nucleolin and drives its oligomerization with specific metastasis-promoting metabolic transcripts, thereby increasing transcript stability and expression. Full-Text PDF