Optimization of a combined wet milling process to produce nanosuspension and its transformation into surfactant-free solid compositionsto increase the product stability and drug bioavailability

This article reports on the effects of a new combined wet milling technique on the physicochemical properties of meloxicam (MEL).The influence of milling time on the particle size, the crystallinity, the morphology and the dissolution rate of MEL has been studied in the presence and absence of polyvinyl alcohol (PVA) as a stabilizer agent.Micronized MEL particles were produced in aqueous medium which did not contain additive after milling for 10 min.For nanonization an additive and longer milling time were required.After particle size determination the structural and morphological characterization of the wet milled, dried products containing MEL were studied.X-ray powder diffractometry (XRPD) and differential scanning calorimetry (DSC) examinations revealed the change in the crystallinity of MEL.Scanning electron microscopy (SEM) images showed that aggregates of nanosized MEL particles were formed, regardless of the presence of PVA.The nanonized MEL crystals (D 50 = 126 nm) exhibited a regular shape and a smooth surface.The increased specific surface area resulted in a high dissolution rate and concentration of free MEL.According to the results, the produced samples could be applied as a basic material (micronized MEL) and intermediate product (micronized and nanonized MEL with PVA) for the design of dosage forms.