Effects of chitosan on the liquid suppository composed of poloxamers in vitro

Objective To study the effects of different concentrations of chitosan on the liquid suppository composed of poloxamers in vitro. Methods Five different concentrations of chitosan (0%, 0.1%, 0.2%, 0.3% and 0.4%, W/W) and poloxamers (P 407 ∶P 188 =15%∶19%, W/W) were used as the liquid suppository bases. The changes of the bases were determined by measuring gel temperature, gel strength and bioadhesive force. Results When the concentration of the chitosan was increased from 0% to 0.4%, the gel temperatures(℃) were 27.8, 28.0, 28.1, 28.4, 28.8 respectively,gel strengths(s)were 12, 40, 86, 107, 168 respectively and bioadhesive forces (×10 2 dyne/cm 2) were 36.9, 50.5, 54.7, 62.2, 85.6 respectively. As the concentration of the chitosan increased, the gel temperature, gel strength and bioadhesive force of the bases were also increased correspondingly. Conclusions Chitosan could improve the quality of liquid suppository composed of poloxamers in vitro.