Evaluation in vitro of 5-fluorouracil Gastric Bioadhesive Tablets

Study on bioadhesion of 5-fluorouracil gastric bioadhesive tablets is the main aim. The bioadhesive force was evaluated by a self-made apparatus, and compared the force of the different formulations. In the same time, the content of swelling and expansion of tablets were also studied. The findings show that the bioadhesion force and the content of swelling and expansion of tablets were different from various formulations. The bioadhesion force, content of swelling and expansion of tablets also were criterions as the reference.