A series of TiO2 photocatalysis with different Fe content were prepared by sol-gel method in this article. Indigo carmine was used as a simulation of pollutants to test its catalytic activity. The results showed that when the content of Fe 0.75 % of all content, illuminating time 4h, the degradation efficiency of indigo carmine rouged up to 99.70%. The TiO2 photocatalytic efficiency could be significantly improved by doping iron.