生物
干扰素调节因子
转录因子
IRF8
造血
免疫学
ETS转录因子家族
癌变
干扰素
内部收益率1
遗传学
细胞生物学
基因
干细胞
作者
Tomohide Tamura,Hideyuki Yanai,David Savitsky,Tadatsugu Taniguchi
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2008-04-01
卷期号:26 (1): 535-584
被引量:1070
标识
DOI:10.1146/annurev.immunol.26.021607.090400
摘要
The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was identified in the late 1980s in the context of research into the type I interferon system. Subsequent studies over the past two decades have revealed the versatile and critical functions performed by this transcription factor family. Indeed, many IRF members play central roles in the cellular differentiation of hematopoietic cells and in the regulation of gene expression in response to pathogen-derived danger signals. In particular, the advances made in understanding the immunobiology of Toll-like and other pattern-recognition receptors have recently generated new momentum for the study of IRFs. Moreover, the role of several IRF family members in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers.
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