Neural Networks (NNs) has emerged as an importance tool for classification in the field of decision making. The main objective of this work is to design the structure and select the optimized parameter in the neural networks to implement the heart disease classifier. Three types of neural networks, i.e. Multi-layered Perceptron Neural Network (MLP-NN), Radial Basis Function Neural Networks (RBF-NN), and Generalized Regression Neural Network (GR-NN) have been used to test the performance of heart disease classification. The classification accuracy obtained by RBFNN gave a very high performance than MLP-NN and GR-NN respectively. The performance of accuracy is very promising compared with the previously reported another type of neural networks.