Systemic inflammatory perturbations triggered by neuropathic pain in L5 compressed mouse and rat model

Our study identifies key genes and signaling pathways that may contribute to systemic inflammation in nerve compression-induced neuropathic pain. We sorted out potential intervention targets to modulate the inflammatory process in neuropathic pain, such as inhibitors of Csf3 and IL13, as well as targeting the IL6/TNF-α pathway. However, further functional validation is necessary to confirm their therapeutic efficacy.