纳米颗粒
微气泡
材料科学
纳米技术
超声波
对比度(视觉)
介孔二氧化硅
纳米尺度
化学工程
介孔材料
化学
有机化学
光学
工程类
物理
催化作用
声学
作者
Qiaofeng Jin,Cheng-Yao Lin,Shih‐Tsung Kang,Yuan-Chih Chang,Hairong Zheng,Chia-Min Yang,Chih‐Kuang Yeh
标识
DOI:10.1016/j.ultsonch.2016.12.001
摘要
Microbubbles have been widely studied as ultrasound contrast agents for diagnosis and as drug/gene carriers for therapy. However, their size and stability (lifetime of 5–12 min) limited their applications. The development of stable nanoscale ultrasound contrast agents would therefore benefit both. Generating bubbles persistently in situ would be one of the promising solutions to the problem of short lifetime. We hypothesized that bubbles could be generated in situ by providing stable air nuclei since it has been found that the interfacial nanobubbles on a hydrophobic surface have a much longer lifetime (orders of days). Mesoporous silica nanoparticles (MSNs) with large surface areas and different levels of hydrophobicity were prepared to test our hypothesis. It is clear that the superhydrophobic and porous nanoparticles exhibited a significant and strong contrast intensity compared with other nanoparticles. The bubbles generated from superhydrophobic nanoparticles sustained for at least 30 min at a MI of 1.0, while lipid microbubble lasted for about 5 min at the same settings. In summary MSNs have been transformed into reliable bubble precursors by making simple superhydrophobic modification, and made into a promising contrast agent with the potentials to serve as theranostic agents that are sensitive to ultrasound stimulation.
科研通智能强力驱动
Strongly Powered by AbleSci AI