纳米载体
免疫系统
CD47型
癌症研究
脂质体
吞噬作用
雌激素受体
癌症
药理学
药品
化学
医学
材料科学
乳腺癌
免疫学
纳米技术
内科学
作者
Yuehua Wang,Zihua Wang,Yixia Qian,Linyang Fan,Chunyan Yue,Fei Jia,Jian Sun,Zhiyuan Hu,Weizhi Wang
摘要
Multifunctional nanocarriers have been widely applied due to their enhanced effect on tumor therapeutics. Nevertheless, owing to the natural immune clearance mechanisms in living bodies, nanocarriers tend to be eliminated during blood circulation, thereby impeding their effective arrival at the tumor sites. Herein, we constructed a synergetic targeted liposome nanocarrier system named SELS functionalized with both a tumor identification ligand (anti-ER (Estrogen Receptor) antibody) and an immune targeting ligand (Self-Peptide (SP)). The anti-ER antibody could recognize and bind ER-positive breast cancer tissues in a specific way. SP could activate the CD47-SIRPα immune response, which reduced phagocytosis of the nanoparticles by macrophages. Both the enhanced targeting ability and anti-phagocytosis behavior could improve the tumor uptake of the nanocarriers and prevent their immune clearance in living systems. Therefore, drug-loaded SELS enabled improved tumor imaging and therapeutic performance in living systems.
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