Cancer Radiotherapy: Enhanced Radiosensitization by Gold Nanoparticles with Acid‐Triggered Aggregation in Cancer Radiotherapy (Adv. Sci. 8/2019)

In article number 1801806, Xing-Jie Liang, Jianfeng Liu, and co-workers develop a gold nanoparticles (GNPs) system with acid-triggered aggregation as a radiosensitizer. With a sensitizer enhancement ratio (SER) value of 1.730 (vs. single GNPs of 1.16), this GNPs system improves sensitivity of MCF-7 cells and MCF-7 tumor xenograft to ionizing radiation. This work provides a strategy for fabricating radiosensitizer by in situ acid-triggered nano-aggregates formation.