对映选择合成
金鸡纳
催化作用
磷化氢
化学
对映体
吡咯
氧化膦
组合化学
配体(生物化学)
对映体过量
戒指(化学)
有机化学
生物化学
受体
作者
Zheng Shi,Qian Wang,Jieping Zhu
标识
DOI:10.1002/anie.201812654
摘要
We report herein the first examples of catalytic enantioselective synthesis of axially chiral 3-arylpyrroles. Reaction of α-isocyanoacetates with β-aryl-α,β-alkynic ketones in the presence of silver oxide and a phosphine ligand derived from Cinchona alkaloid occurred chemoselectively to afford enantioenriched 3-arylpyrroles in high yields with excellent enantiomeric excesses. The pyrrole ring was constructed de novo in this process.
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