化学
催化作用
二醇
氢原子
邻接
光异构化
光化学
动力控制
异构化
组合化学
有机化学
群(周期表)
作者
Yu An Zhang,Xin Gu,Alison E. Wendlandt
摘要
Here, we report the selective, catalytic isomerization of cis-1,2-diols to trans-diequatorial-1,2-diols. The method employs triphenylsilanethiol (Ph3SiSH) as a catalyst and proceeds under mild conditions in the presence of a photoredox catalyst and under blue light irradiation. The method is highly chemoselective, broadly functional group tolerant and provides concise access to trans-diol products which are not readily obtained using other methods. Mechanistic studies reveal that isomerization proceeds through a reversible hydrogen atom transfer pathway mediated by the silanethiol catalyst.
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