效应器
生物
抑制因子
转录因子
细胞生物学
STAT蛋白
基因
抄写(语言学)
基因表达调控
激活剂(遗传学)
麦格纳波特
遗传学
信号转导
格里斯麦格纳波特
车站3
水稻
语言学
哲学
作者
Xinyu Liu,Yixin Gao,Ziqian Guo,Nian Wang,Alex Wegner,Jintao Wang,Xi Zou,Jiexiong Hu,Muxing Liu,Haifeng Zhang,Xiaobo Zheng,Ping Wang,Ulrich Schaffrath
摘要
Summary Magnaporthe oryzae secretes several effectors that modulate and hijack rice processes to colonize host cells, but the underlying mechanisms remain unclear. We report on a novel cytoplasmic effector MoIug4 that targets the rice ethylene pathway as a transcription repressor to subvert host immunity. We found that MoIug4 binds to the promoter of the host OsEIN2 gene that encodes a central signal transducer in the ethylene‐signaling pathway. We also identified a MoIug4 interacting protein, OsAHL1, which acts as an AT‐hook motif‐containing protein binding to the A/T‐rich promoter regions. Our knockout and overexpression studies showed that OsAHL1 positively regulates plant immunity in response to M. oryzae infection. OsAHL1 exhibits transcriptional regulatory activities by binding the OsEIN2 promoter region, similar to MoIug4. Intriguingly, we found that MoIug4 exhibits a higher binding affinity than OsAHL1 to the OsEIN2 promoter, suggesting differential regulatory specificities. These results revealed a counter‐defense strategy by which the pathogen effector suppresses the activation of host defense genes by interfering with host transcription activator functions.
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