头孢克肟
化学计量学
循环伏安法
生物传感器
电极
伏安法
胶体金
材料科学
四环素
分析化学(期刊)
纳米颗粒
色谱法
化学
纳米技术
电化学
抗生素
生物化学
物理化学
头孢菌素
作者
M. Asadollahi-Baboli,Ahmad Mani-Varnosfaderani
出处
期刊:Measurement
[Elsevier]
日期:2014-01-01
卷期号:47: 145-149
被引量:57
标识
DOI:10.1016/j.measurement.2013.08.029
摘要
The screen-printed gold electrode (SPGE) modified with the formation of self-assembly monolayer (SAM) of cysteine (Cys) on gold-nanoparticles (Aunano) was utilized for rapid and simultaneous determination of tetracycline and cefixime antibiotics by square wave voltammetry (SWV). Electrochemical investigation and characterization of the modified electrode was achieved using cyclic voltammetry (CV) and scanning electron microscopy (SEM). A principal component artificial neural network (PCANN) with three layer back-propagation network was utilized for the analysis of the voltammogram data. It is possible to simultaneously determine the tetracycline and cefixime concentrations in the ranges of 10−5 and 10−3 mol L−1, under the optimum conditions. Moreover the SPGE-Aunano-Cys biosensor together with chemometrics tools was successfully applied to the determination of tetracycline and cefixime in biological fluids, which may provide a promising alternative in routine biosensing applications.
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