Wnt信号通路
细胞凋亡
癌症研究
干瘪的
生物
癌变
细胞生长
医学
信号转导
癌症
内科学
细胞生物学
遗传学
生物化学
作者
Sebastian Öther-Gee Pohl,Ross Scott,Philip Newsholme,Vanathi Perumal,Arun Dharmarajan
出处
期刊:Tumor Biology
[SAGE]
日期:2015-01-01
卷期号:36 (1): 143-152
被引量:30
标识
DOI:10.1007/s13277-014-2956-z
摘要
Secreted frizzled-related protein 4 (SFRP4) is a glycoprotein that acts as an antagonist of Wnt ligands, causing inhibition of the canonical Wnt signalling pathway. First noticed due to high expression levels during times of increased apoptosis, SFRP4 has been implicated in cell proliferation and differentiation and plays an important role in carcinogenesis. Many tumours such as endometrial, cervical, ovarian, prostate, bladder, colorectal, mesothelioma, pancreatic, renal, and oesophageal tumours are characterised by aberrant promoter hypermethylation, which causes variations in the expression level of SFRP4 when compared to normal cells. Combined experimental data appear to confirm the suggested role of SFRP4 as a local initiator of apoptosis; however, increased SFRP4 expression may not always correlate with an increase in apoptosis, possibly due to the complex interactions between different signalling pathways. SFRP4 can be explored for its use in novel therapeutic modalities as well as being a potential diagnostic biomarker.
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