化学
电泳剂
四氢呋喃
产量(工程)
烷基化
烷基
丁基锂
有机化学
药物化学
催化作用
溶剂
材料科学
冶金
作者
Christopher J. Moody,Charles W. Rees,Richard G. Young
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:1990-01-01
卷期号:1990 (07): 413-414
被引量:11
摘要
Treatment of 1- and 2-alkyl-5-phenyltetrazoles with tert-butyllithium in tetrahydrofuran at -78 °C gives "dipole-stabilised" α-lithioalkyl derivatives which are readily converted into the corresponding deuterated, silylated, alkylated, hydroxymethylated, acylated and carboxylated derivatives, mostly in high yield. Lithiation of 5-phenyl-2-trimethylsilylmethyltetrazole followed by reaction with aldehydes results in Peterson olefination to give 2-alkenyltetrazoles in good yield.
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