基因剔除小鼠
行为绝望测验
心理学
高架加迷宫
受体
表型
焦虑
Sigma-1受体
神经科学
基因敲除
西格玛
抗抑郁药
野生型
内分泌学
内科学
突变体
生物
兴奋剂
医学
精神科
基因
遗传学
物理
量子力学
作者
Valentina Sabino,Pietro Cottone,Sarah Parylak,Luca Steardo,Eric P. Zorrilla
标识
DOI:10.1016/j.bbr.2008.11.036
摘要
Activation of sigma-1 receptors (Sig-1R) reportedly has antidepressant-like action. Limited data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present experiments measured depressive-like, anxiety-like and motor behavior in Sig-1R knockout mice and their wildtype littermates. Sig-1R knockout mutants showed increased immobility in the forced swimming test, a depressive-like phenotype, but normal anxiety-like behavior in the elevated plus-maze and light/dark box tests and normal locomotor activity. The results further suggest that Sig-1Rs inversely modulate depressive-like behavior.
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