Dry Eye as a Major Complication Associated with Chronic Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation

We report a significant role for stromal fibroblasts in the pathogenic processes of dry eye related to chronic GVHD. Although several supportive therapies can reduce the symptoms, specific therapies that suppress fibrotic and immune processes in the lacrimal glands are necessary to control dry eye associated with chronic GVHD.