CuO/ZnO catalysts with different CuO content were prepared by deposition-precipitation method for water-gas shift reaction,using Cu(OH)2 as the precursor of CuO.The as-prepared catalysts were characterized by N2-physisorption,TPR and XRD.The results showed that catalytic activity of the as-prepared catalysts was influenced by the dispersion and particles size of CuO as well as the interaction between CuO and ZnO.20wt%CuO/ZnO catalyst exhibited superior catalytic activity for water-gas shift reaction,with CO conversion of 95.5% at 350 ℃.