Change of synapsins in hippocampal formation during spacial learning and memory in rats

AIM and METHODS: The immunohistochemical method was used to study the on synapsin ex- press in hippocampal formation during spatial learning and memory in rats. RESULTS: (1 ) In control group there are diffuse brown granules without any obvious granular product in hippocampal fornation and in model group there are synapsin products in the hippocampal formation, especially in the subregion CA3, CA4 and the dentate gyrus after water maze flamed for one week. After two weeks water maze thened the hippocampal formation appear the same dis- tribution of the product edes with darker staining. (2) The light dendity of synapsin products between the model and the control groups showed significant differences, that in the model group was highter than that in the control group (P0. 05). The light dendity of synapsin producgts increased with the training time from the first week to the second week in the model group. And there is no increase with the thening the time the second week to the third week. The light dendity is higher in the CA3, CA4 subregion and the dentate acs than the CA1 and CA2 subregion (P 0. 05). CONCLUSIONS: (1) As mentioned above, it is believed that the new synapes are formed in the hip- pocampal formation of the rat by spacial learning and memory training. (2) The CA3, CA4 subregion and the dentate gyms are correlated with the spacial learning and memory.