化学
立体选择性
瓶颈
组合化学
氨基酸
产量(工程)
可扩展性
有机化学
生物化学
计算机科学
催化作用
数据库
嵌入式系统
冶金
材料科学
作者
Ayush Patel,Xiang‐Guo Hu,Aggie Lawer,Mohammad Bashir Ahmed,Catherine Au,Rasha Saad Jwad,Johny Trinh,Christina Gonzalez,Elizabeth Hannah,Mohan Bhadbhade,Luke Hunter
出处
期刊:Tetrahedron
[Elsevier]
日期:2016-06-01
卷期号:72 (23): 3305-3317
被引量:15
标识
DOI:10.1016/j.tet.2016.04.070
摘要
Backbone-fluorinated gamma-amino acids are novel shape-controlled building blocks that have potential utility in a variety of biological contexts. However, their synthesis poses challenges in terms of chemo-, regio- and stereoselectivity, and this has proven to be the major bottleneck in the ongoing development of their various biological applications. To address this problem, several new synthetic strategies were investigated in this work. This has led to the identification of new methods that are superior in terms of yield and stereocontrol.
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