刮伤
脾后皮质
神经科学
组胺能
边缘下皮质
扣带回前部
皮质(解剖学)
运动前神经元活动
心理学
扣带皮质
医学
中枢神经系统
前额叶皮质
受体
认知
内科学
物理
声学
作者
Jun-Hui Long,Pu-Jun Wang,Zhi-Fang Li,Juan Yao,Xuan Li,Bing Wu,Jian-Feng Sui,Jun Liao,Ping Wang,Xiao-Feng Li,Shu-Lei Liu
标识
DOI:10.1016/j.bbr.2023.114306
摘要
Itch is an unpleasant sensation followed by an intense desire to scratch. Previous researches have advanced our understanding about the role of anterior cingulate cortex and prelimbic cortex in itch modulation, whereas little is known about the effects of retrosplenial cortex (RSC) during this process. Here we firstly confirmed that the neuronal activity of dysgranular RSC (RSCd) is significantly elevated during itch-scratching processing through c-Fos immunohistochemistry and fiber photometry recording. Then with designer receptors exclusively activated by designer drugs approaches, we found that pharmacogenetic inhibition of global RSCd neurons attenuated the number of scratching bouts as well as the cumulative duration of scratching bouts elicited by both 5-HT or compound 48/80 injection into rats' nape or cheek; selective inhibition of the pyramidal neurons in RSCd, or of the excitatory projections from caudal anterior cingulate cortex (cACC) to RSCd, demonstrated the similar effects of decreasing itch-related scratching induced by both 5-HT or compound 48/80. Pharmacogenetic intervention of the neuronal or circuitry activities did not affect rats' motor ability. This study presents direct evidence that pyramidal neurons in RSCd, and the excitatory projection from cACC to RSCd are critically involved in central regulation of both histaminergic and nonhistaminergic itch.
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