BF3·Et2O controlled selective synthesis of α-substituted propargylamides and β-(N-acylamino) ketones: application to carbon and sulphur nucleophiles

This study presents a metal-free and selective synthesis of α-substituted propargylamides and β-( N -acylamino) ketones utilizing nitriles, aldehydes, and terminal alkynes, mediated by BF 3 ·Et 2 O.