Radiomics Harmonization in Ultrasound Images for Cervical Cancer Lymph Node Metastasis Prediction Using Cycle-GAN

Background: Ultrasound (US) based radiomics is susceptible to variations in scanners, sonographers. Objective: To retrospectively investigate the feasibility of an adapted cycle generative adversarial networks (CycleGAN) in the style transfer to improve US based radiomics in the prediction of lymph node metastasis (LNM) with images from multiple scanners for patients with early cervical cancer (ECC). Methods: The CycleGAN was firstly trained to transfer paired US phantom images from one US device to another one; the model was then further trained and tested with clinical US images of ECC by transferring images from four US devices to one specific device; finally, the adapted model was tested with its effects on the radiomics feature harmonization and accuracy of LNM prediction in US based radiomics for ECC patients. Results: Phantom study demonstrated an increased radiomics harmonization using CycleGAN with an average Pearson correlation coefficient of 0.60 and 0.81 for radiomics features extracted from original and generated images in correlation with the target phantom images, respectively. Additionally, the image quality metric Peak Signal-to-Noise Ratio (PSNR) was increased from 11.18 for the original images to 15.45 for the generated image. Clinical US images of 169 ECC patients were enrolled for style transfer model training and validation. The area under curve (AUC) of LNM prediction radiomics models with features extracted from generated images of different style transfer models ranged from 0.73 to 0.85. The AUC was improved from 0.78 with features extracted from original images to 0.85 with style transferred images. Conclusions: The adapted CycleGAN network is able to increase the radiomics feature harmonization for images from different ultrasound equipment based on image domain and improve the LNM prediction accuracy for ECC.