兴奋性突触后电位
神经性厌食
病态的
抑制性突触后电位
谷氨酸受体
质子磁共振
神经传递
神经科学
内科学
谷氨酸的
医学
心理学
内分泌学
精神科
核磁共振
饮食失调
物理
受体
作者
Jules Mitchell,Toomas Erik Anijärv,Jacob M. Levenstein,Daniel F. Hermens,Jim Lagopoulos
标识
DOI:10.1016/j.neubiorev.2023.105279
摘要
The dysregulation of excitatory and inhibitory neurotransmission is considered a pathological marker of Anorexia Nervosa (AN), however, no systematic evaluation of the proton Magnetic Resonance Spectroscopy (1H-MRS) literature has been conducted to date. Accordingly, we conducted a systematic review of neurometabolite differences between individuals with AN and healthy controls (HC). A comprehensive database search (until June 2023) identified seven studies meeting inclusion criteria. Samples included adolescents and adults with similar mean age (AN: 22.20 HC: 22.60), and female percentages (AN: 98%; HC: 94%). The review found a considerable need for improving study design and the reporting of MRS sequence parameters and analysis. Reduced glutamate concentrations in the ACC and OCC, and reduced Glx concentrations in the ACC were reported by one and two studies, respectively. Lastly, only one study to date has quantified GABA concentrations, with no significant differences found. In conclusion, there is currently insufficient evidence of excitatory and inhibitory neurometabolites changes in AN. As the 1H-MRS literature in AN increases, the key questions herein proposed must be revisited.
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