生物
平衡
FOXP3型
免疫系统
细胞生物学
免疫
旁分泌信号
细胞代谢
白细胞介素2受体
Treg细胞
功能(生物学)
调节性T细胞
免疫学
细胞
T细胞
生物化学
受体
作者
Paola de Candia,Claudio Procaccini,Claudia Russo,Maria Teresa Lepore,Giuseppe Matarese
出处
期刊:Immunity
[Elsevier]
日期:2022-11-01
卷期号:55 (11): 1981-1992
被引量:17
标识
DOI:10.1016/j.immuni.2022.10.006
摘要
Compelling experimental evidence links immunity and metabolism. In this perspective, we propose forkhead-box-P3 (FoxP3)+CD4+CD25+ regulatory T (Treg) cells as key metabolic sensors controlling the immunological state in response to their intrinsic capacity to perceive nutritional changes. Treg cell high anabolic state in vivo, residency in metabolically crucial districts, and recirculation between lymphoid and non-lymphoid sites enable them to recognize the metabolic cues and adapt their intracellular metabolism and anti-inflammatory function at the paracrine and systemic levels. As privileged regulators at the interface between neuroendocrine and immune systems, the role of Treg cells in maintaining metabolic homeostasis makes these cells promising targets of therapeutic strategies aimed at restoring organismal homeostasis not only in autoimmune but also metabolic disorders.
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