Co-learning of appearance and shape for precise ejection fraction estimation from echocardiographic sequences

Accurate estimation of ejection fraction (EF) from echocardiography is of great importance for evaluation of cardiac function. It is usually obtained by the Simpson's bi-plane method based on the segmentation of the left ventricle (LV) in two keyframes. However, obtaining accurate EF estimation from echocardiography is challenging due to (1) noisy appearance in ultrasound images, (2) temporal dynamic movement of myocardium, (3) sparse annotation of the full sequence, and (4) potential quality degradation during scanning. In this paper, we propose a multi-task semi-supervised framework, which is denoted as MCLAS, for precise EF estimation from echocardiographic sequences of two cardiac views. Specifically, we first propose a co-learning mechanism to explore the mutual benefits of cardiac segmentation and myocardium tracking iteratively on appearance level and shape level, therefore alleviating the noisy appearance and enforcing the temporal consistency of the segmentation results. This temporal consistency, as shown in our work, is critical for precise EF estimation. Then we propose two auxiliary tasks for the encoder, (1) view classification to help extract the discriminative features of each view, and automatize the whole pipeline of EF estimation in clinical practice, and (2) EF regression to help regularize the spatiotemporal embedding of the echocardiographic sequence. Both two auxiliary tasks can improve the segmentation-based EF prediction, especially for sequences of poor quality. Our method is capable of automating the whole pipeline of EF estimation, from view identification, cardiac structures segmentation to EF calculation. The effectiveness of our method is validated in aspects of segmentation, tracking, consistency analysis, and clinical parameters estimation. When compared with existing methods, our method shows obvious superiority for LV volumes on ED and ES phases, and EF estimation, with Pearson correlation of 0.975, 0.983 and 0.946, respectively. This is a significant improvement for echocardiography-based EF estimation and improves the potential of automated EF estimation in clinical practice. Besides, our method can obtain accurate and temporal-consistent segmentation for the in-between frames, which enables it for cardiac dynamic function evaluation.