下调和上调
再灌注损伤
巨噬细胞
缺血
衣康酸
心肌缺血
药理学
医学
化学
心脏病学
生物化学
体外
共聚物
基因
有机化学
聚合物
作者
Sixuan Chen,Haojie Yao,Yanmei Lou,Huihui Wang,Baoping Xie,Junxuan Wu,Xiaoxiao Qi,Ying Wang,Peng Wu,Rong Zhang,Zhongqiu Liu,Yuanyuan Cheng
标识
DOI:10.1016/j.jare.2024.09.024
摘要
PBC alleviates MIRI-induced cardiomyocyte apoptosis by modulating the HSP90/ITA/PKM2 axis. Furthermore, pharmacological upregulation of ITA emerges as a promising therapeutic approach for MIRI, hinting at PBC's potential as a candidate drug for MIRI therapy.
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