氧化应激
医学
对氧磷酶
甲基化
趋化因子
自闭症
自闭症谱系障碍
四氯化碳
内科学
生物信息学
免疫学
肿瘤科
炎症
精神科
生物
生物化学
基因
作者
Moushira Zaki,Eman R. Youness,Hisham A. Orban,Hend Ahmed,Rehab I. Moustafa,Fatma Abdelrahman Alzaree,Engy A. Ashaat,Hala T. El‐Bassyouni
标识
DOI:10.1515/jcim-2024-0145
摘要
Abstract Objectives The study aimed to assess the effect of these biomarkers on a sample of children with autism spectrum disorder (ASD) to help in early diagnosis and intervention. Methods A total of 71 autistic patients and 65 normal controls were enrolled in this study. Their ages ranged from 5 to 11 years (mean ± SD 7.47 ± 3.81). Childhood Autism Rating Scale (CARS) was assessed for all patients and controls. Assessment of oxidative stress, monocyte chemoattractant protein-1, B-cell lymphoma 2, S-adenosylhomocysteine (SAH), and apelin was performed. Results Oxidative stress (oxidized low-density lipoprotein and malonaldehyde) increased while antioxidant paraoxonase (PON) decreased. Monocyte chemoattractant protein-1, B-cell lymphoma 2, and S-adenosylhomocysteine (SAH) were all elevated whereas, apelin was downregulated. Conclusions It is important to note that many factors that may contribute to ASD including genetic factors. To open the door for novel treatment strategies, it is still necessary to precisely understand how oxidative stress, chemokines, apoptosis, and methylation capability affect the metabolism of people with ASD.
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