明胶
脚手架
纳米复合材料
纳米颗粒
组织工程
材料科学
细胞外基质
纳米技术
骨组织
生物医学工程
化学
工程类
有机化学
生物化学
作者
Elaheh Salehi Abar,Somayeh Vandghanooni,Ali Torab,Mehdi Jaymand,Morteza Eskandani
标识
DOI:10.1016/j.ijbiomac.2023.127556
摘要
The creation of a suitable scaffold is a crucial step in the process of bone tissue engineering (BTE). The scaffold, acting as an artificial extracellular matrix, plays a significant role in determining the fate of cells by affecting their proliferation and differentiation in BTE. Therefore, careful consideration should be given to the fabrication approach and materials used for scaffold preparation. Natural polypeptides such as gelatin and collagen have been widely used for this purpose. The unique properties of nanoparticles, which vary depending on their size, charge, and physicochemical properties, have demonstrated potential in solving various challenges encountered in BTE. Therefore, nanocomposite biomaterials consisting of polymers and nanoparticles have been extensively used for BTE. Gelatin has also been utilized in combination with other nanomaterials to apply for this purpose. Composites of gelatin with various types of nanoparticles are particularly promising for creating scaffolds with superior biological and physicochemical properties. This review explores the use of nanocomposite biomaterials based on gelatin and various types of nanoparticles together for applications in bone tissue engineering.
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