丹特罗琳
兰尼定受体
医学
咖啡因
兰尼碱受体2
心脏病学
恶性高热
钙
离体
麻醉
内科学
药理学
体内
生物
生物技术
作者
Sharon A. George,Jaclyn A. Brennan,Katy A Trampel,Eric Rytkin,Ndeye Rokhaya Faye,Björn C. Knollmann,Igor R. Efimov
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology
[American Physiological Society]
日期:2023-10-01
卷期号:325 (4): H720-H728
被引量:2
标识
DOI:10.1152/ajpheart.00103.2023
摘要
Ryanodine receptor 2 hyperactivity is observed in structural heart diseases caused by ischemia or heart failure. It causes abnormal calcium leaks, which can trigger arrhythmias. To prevent arrhythmias, we applied dantrolene in human hearts ex vivo. Isoproterenol and caffeine treatment increased PVC incidence, whereas dantrolene reduced the PVC burden. Dantrolene treatment suppresses triggers and reverses arrhythmogenic substrates and could be a novel antiarrhythmic therapy in patients with structural heart disease.
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