Electrochemical Analysis of the Antihistamine Drug Cetirizine at a Poly(Glutamine) Modified Carbon Nanotube Paste Electrode

Abstract An inexpensive and efficient sensor was developed for the electrochemical analysis of the antihistamine drug cetirizine (CTZ). The active sites on the bare carbon nanotube paste electrode surface were improved by the electropolymerization of poly(Glutamine). This modified electrode enhances the electrochemical response of the examining molecule. The study was conducted using a cyclic voltammetry technique in phosphate buffer saline of physiological pH 7.0 at a scan rate of 0.1 V/s. The developed electrode possesses increased conductance and declined overpotential for the determination of CTZ. At the optimized conditions, the detection limit was evaluated by obtaining the current response of CTZ at the varied concentration, and it was obtained as 0.12 μM. The poly glutamine modified carbon nanotube paste electrode was successfully applied to determine CTZ in tablet and human urine samples with acceptable recovery.