癫痫
医学
荟萃分析
癫痫发生
生物标志物
创伤性脑损伤
内科学
冲程(发动机)
心理信息
梅德林
精神科
机械工程
生物化学
化学
政治学
法学
工程类
作者
Shubham Misra,Erum Khan,Tu Kiet T. Lam,Rajarshi Mazumder,Kapil Gururangan,L. Brian Hickman,Vaibhav Goswami,Melissa Funaro,Ece Eldem,Lauren H Sansing,Jason J. Sico,Terence J. Quinn,David S Liebeskind,Joan Montaner,Patrick Kwan,Nishant K. Mishra
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:2023-11-28
卷期号:101 (22)
标识
DOI:10.1212/wnl.0000000000207749
摘要
Background and ObjectivesEpilepsy may result from various brain injuries, including stroke (ischemic and hemorrhagic), traumatic brain injury, and infections. Identifying shared common biological pathways and biomarkers of the epileptogenic process initiated by the different injuries may lead to novel targets for preventing the development of epilepsy. We systematically reviewed biofluid biomarkers to test their association with the risk of post–brain injury epilepsy.MethodsWe searched articles until January 25, 2022, in MEDLINE, Embase, PsycInfo, Web of Science, and Cochrane. The primary outcome was the difference in mean biomarker levels in patients with and without post–brain injury epilepsy. We used the modified quality score on prognostic studies for risk of bias assessment. We calculated each biomarker's pooled standardized mean difference (SMD) and 95% CI. Molecular interaction network and enrichment analyses were conducted in Cytoscape (PROSPERO CRD42021297110).ResultsWe included 22 studies with 1,499 cases with post–brain injury epilepsy and 7,929 controls without post–brain injury epilepsy. Forty-five biomarkers in the blood or CSF were investigated with samples collected at disparate time points. Of 22 studies, 21 had a moderate-to-high risk of bias. Most of the biomarkers (28/45) were investigated in single studies; only 9 provided validation data, and studies used variable definitions for early-onset and late-onset seizures. A meta-analysis was possible for 19 biomarkers. Blood glucose levels in 4 studies were significantly higher in patients with poststroke epilepsy (PSE) than those without PSE (SMD 0.44; CI 0.19–0.69). From individual studies, 15 biomarkers in the blood and 7 in the CSF were significantly associated with post–brain injury epilepsy. Enrichment analysis identified that the significant biomarkers (interleukin [IL]–6, IL-1β]) were predominantly inflammation related.DiscussionWe cannot yet recommend using the reported biomarkers for designing antiepileptogenesis trials or use in the clinical setting because of methodological heterogeneity, bias in the included studies, and insufficient validation studies. Although our analyses indicate the plausible role of inflammation in epileptogenesis, this is likely not the only mechanism. For example, an individual's genetic susceptibilities might contribute to his/her risk of epileptogenesis after brain injury. Rigorously designed biomarker studies with methods acceptable to the regulatory bodies should be conducted.
科研通智能强力驱动
Strongly Powered by AbleSci AI