The Significance of System Suitability in High-Performance Liquid Chromatography (HPLC) Analysis: Ensuring Accurate and Reliable Results

High-Performance Liquid Chromatography (HPLC) has emerged as a fundamental technique in modern analytical chemistry, serving as a powerful tool for the separation, identification, and quantification of [1] diverse compounds. One critical aspect that ensures the validity and credibility of HPLC results is the concept of system suitability. This abstract highlights the importance of system suitability in HPLC analysis, emphasizing its role in ensuring accurate and reliable results. System suitability is a set of pre-defined criteria that evaluate the performance of the HPLCsystem, encompassing factors such as resolution, peak symmetry, tailing factor, retention time, and peak area reproducibility. Adhering to these criteria is essential for consistent and precise analyses, as they confirm that the instrument is operating optimally and capable of generating dependable data