食管鳞状细胞癌
医学
阶段(地层学)
内科学
食管癌
癌
肿瘤科
人口
中国人口
胃肠病学
体细胞
癌症
病理
生物
基因
遗传学
基因型
古生物学
环境卫生
作者
Zhen Liu,Mengfei Liu,Ying Liu,Ren Zhou,Amir Abliz,Wenqing Yuan,Chuanhai Guo,Lixin Zhang,He Wang,Hongchen Zheng,Yi Huang,Yaqi Pan,Fangfang Liu,Zhe Hu,Huanyu Chen,Hong Cai,Zhonghu He,Yang Ke
标识
DOI:10.1016/j.xcrm.2023.101168
摘要
The genomic characteristics during the carcinogenic process of esophageal squamous cell carcinoma (ESCC) remain largely unknown. We report here the genomic characteristics of 106 esophageal tissues of various stages from a population-based screening cohort in China ("Endoscopic Screening for Esophageal Cancer in China" trial) and 57 ESCC tissues from a local hospital. A significant increase in somatic mutation and copy number alterations is observed in the non-dysplastic Lugol unstaining lesions (ND-LULs). Extensive clonal expansion has emerged in the ND-LULs to an extent similar to that in higher-stage lesions. The burden of genomic alterations correlates with the size of LULs in the ND-LULs. 8-year follow-up shows that ND-LULs harbor an increased risk of progression to ESCC (adjusted IRR6-10 mm vs. none = 4.66, adjusted IRR>10 mm vs. none = 40.70), and the risk is correlated with LUL size for both non-dysplastic and dysplastic lesions. Lugol unstaining can be the initial stage in the carcinogenic process of ESCC.
科研通智能强力驱动
Strongly Powered by AbleSci AI