Copper‐Catalyzed Synthesis of β‐Alkynyl Ketones from Propargylic Alcohols and Enamides

Abstract An efficient method to access β‐alkynyl ketones from propargylic alcohols and enamides under copper catalysis was developed. This methodology allows access to a series of highly functionalized β‐alkynyl ketones in moderate to excellent yields under mild conditions. Moreover, the resultant products could further be transformed to various valuable scaffolds with potential biological activities.