Hypoxia‐Responsive Photosensitizer Targeting Dual Organelles for Photodynamic Therapy of Tumors (Small 1/2023)

Photodynamic Therapy of Tumors In article number 2205440, Zhiyang Liu, Quan Li, and co-workers exploit the hypoxic properties of solid tumors to construct a hypoxia-responsive photosensitizer. When the non-fluorescent hypoxia-responsive photosensitizer enters the hypoxic tumors, it is reduced by the overexpressed azoreductase to generate the fluorescent photosensitizer with the aggregation-induced emission property, which can realize the fluorescence-activatable image-guided photodynamic therapy with dual-organelle (lipid droplets and lysosomes) targeting.