渗出液
伤口愈合
细胞外基质
透明质酸
成纤维细胞
脚手架
材料科学
纳米纤维
生物医学工程
自愈水凝胶
化学
医学
纳米技术
外科
体外
生物化学
解剖
病理
高分子化学
作者
Liheng Gao,Xingxing Liu,Wenshuo Zhao,Chaojing Li,Fujun Wang,Xinzhe Zhao,Xinqin Liao,Lei Wei,Hao Wu,Yuanjin Zheng,Lu Wang
出处
期刊:Biofabrication
[IOP Publishing]
日期:2022-12-29
卷期号:15 (1): 015021-015021
被引量:2
标识
DOI:10.1088/1758-5090/acaa01
摘要
Dynamic regulation of wound physiological signals is the basis of wound healing. Conventional biomaterials delivering growth factors to drive wound healing leads to the passive repair of soft tissues because of the mismatch of wound healing stages. Meanwhile, the bioactivity of wound exudate is often restricted by oxidation and bacterial contamination. Herein, an extracellular matrix mimicked nanofiber/hydrogel interpenetrated network (NFHIN) was constructed with a 3D nanofibrous framework for cell immigration, and interfiled aerogel containing cross-linked hyaluronic acid and hyperbranched polyamidoamine to balance the wound microenvironment. The aerogel can collect wound exudate and transform into a polycationic hydrogel with contact-killing effects even against intracellular pathogens (bactericidal rate > 99.9% in 30 min) and real-time scavenging property of reactive oxygen species. After co-culturing with the NFHIN, the bioactivity of fibroblast in theex vivoblister fluid was improved by 389.69%. The NFHIN showed sustainable exudate management with moisture-vapor transferring rate (6000 g m-2×24 h), equilibrium liquid content (75.3%), Young's modulus (115.1 ± 7 kPa), and anti-tearing behavior similar to human skin. The NFHIN can collect and activate wound exudate, turning it from a clinical problem to an autoimmune-derived wound regulation system, showing potential for wound care in critical skin diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI