Effects of Cytomegalovirus-Induced Neuroinflammation on Central Nervous System Development

Abstract Congenital cytomegalovirus (cCMV) infection is associated with long-term central nervous system sequelae, including sensorineural hearing loss and neurodevelopmental delay, but mechanisms of neuropathogenesis in the developing fetal brain are incompletely understood. Animal models biologically representative of congenital infection have been used to characterize the effects of cCMV on neurogenesis, brain development, and cochlear development. Murine models utilizing host transcriptional analyses have been helpful in understanding the inflammatory response to cCMV infection and have demonstrated a correlation between elevation of proinflammatory mediators and altered brain and cochlear morphology during development. In this article, we review mechanisms of neuropathogenesis in cCMV animal models, with particular focus on the role of CMV-induced neuroinflammation in the impairment of fetal brain development.