Review of collagen type I-based hydrogels: focus on composition-structure-properties relationships

This review explores each stage of Collagen type I (Coll-I) hydrogel development, highlighting how sourcing, extraction, solubilization, and modification (e.g., blending, crosslinking, and composite formation) influence its gelation, and structural, mechanical, and biological properties. By clarifying key interrelations among these characteristics, this work serves as a valuable guide for scientists designing next-generation of Coll-I-based hydrogels with optimized properties for tissue engineering and regenerative medicine applications.