Synthetic Studies Toward Daphnezomines A and B

Abstract Synthetic studies toward daphnezomines A and B, members of Daphniphyllum alkaloid group with a rare azaadamantane core structure, are reported. The tricyclic carbon skeleton with two contiguous quaternary carbon centers was synthesized in nine steps from (R)-piperitone. An intramolecular Tsuji–Trost reaction was used as a key reaction for the assembly of the skeleton.