鼻咽癌
人口
入射(几何)
医学
爱泼斯坦-巴尔病毒
家族史
内科学
队列
病毒
队列研究
免疫学
肿瘤科
环境卫生
光学
物理
放射治疗
作者
James C.H. Chow,Anne W.M. Lee,Charlene Wong,Wai Tong Ng,Zhiwei Liu,Joshua K. Tay,Kwok Seng Loh,Pia Pace‐Asciak,Oded Cohen,June Corry,Juan P. Rodrigo,Raymond K. Y. Tsang,Fernándo López,Nabil F. Saba,Remco de Bree,Alfio Ferlito
出处
期刊:Oral Oncology
[Elsevier]
日期:2022-10-01
卷期号:133: 106031-106031
被引量:1
标识
DOI:10.1016/j.oraloncology.2022.106031
摘要
Evidence to support Epstein-Barr virus (EBV)-directed population nasopharyngeal carcinoma (NPC) screening has been growing. Familial aggregation is a well-recognized phenomenon in endemic regions. This systematic review summarizes the role of EBV-directed screening in individuals with a positive family history (FH+) of NPC.We searched four electronic databases from their inception to October 2021. We included studies on individuals with FH+ of NPC who had undergone EBV-directed investigations, with no restriction in the testing methods or analytic techniques. The primary and secondary outcomes were EBV positivity rates and NPC incidence rates, respectively. Meta-analyses were performed using the random-effect model.Ten cross-sectional studies (n = 7436) and three cohort studies (n = 4306) were included. The pooled relative risk (RR) of EBV positivity between individuals with and without FH+ of NPC were 2.79 (95 % CI 1.37-5.68, p = 0.005) for viral capsid antigen (VCA) IgA, 3.09 (95 % CI 0.65-14.83, p = 0.16) for Epstein-Barr nuclear antigen (EBNA1) IgA, and 1.76 (95 % CI 1.04-2.96, p = 0.03) for combined EBNA1/VCA IgA. In the three cohort studies, the NPC incidence rates ranged from 90.2 to 266 per 100 000 person-years with high proportions of early-stage diseases. FH+ individuals who were EBV-positive had a 2.5 to 30.7-fold risk of NPC development compared to their EBV-negative counterparts.Family members of NPC patients had significantly higher EBV positivity rates than the general population. FH+ individuals who are EBV-positive had high risks of developing NPC. Familial screening using EBV serology may facilitate early NPC detection in endemic areas.
科研通智能强力驱动
Strongly Powered by AbleSci AI