分子内力
弗里德尔-克拉夫茨反应
原子经济
化学
苯氮卓类
基质(水族馆)
范围(计算机科学)
组合化学
立体化学
有机化学
计算机科学
催化作用
海洋学
程序设计语言
地质学
作者
Yuzhu Zheng,Qing Huang,Fang Xiong,Youwei Xie
标识
DOI:10.1021/acs.joc.3c01977
摘要
We describe a Re2O7-mediated intramolecular dehydrative Friedel–Crafts reaction for the efficient synthesis of various benzo-fused heterocycles such as benzazepines and benzazocines. This process is characterized by a broad substrate scope, mild reaction conditions, high efficiency, and high atom economy. The potential application of this methodology was exemplified by the facile preparation of a NMDA antagonist as well as a key intermediate en route to SKF 38393.
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