圆二色性
发色团
DNA
DNA折纸
化学物理
激子
荧光
化学
分子动力学
DNA纳米技术
生物物理学
合理设计
二聚体
纳米技术
材料科学
结晶学
计算化学
物理
光化学
光学
生物
量子力学
有机化学
生物化学
作者
Xiaomei Mo,Huacheng Li,Pan Tang,Yaya Hao,Bin Dong,M.D. Marazuela,M. Milagros Gómez-Gómez,Xindong Zhu,Qian Li,Beatriz Lora Maroto,Shuoxing Jiang,Chunhai Fan,Xiang Lan
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-12-11
卷期号:23 (24): 11734-11741
标识
DOI:10.1021/acs.nanolett.3c03652
摘要
Study of the conformational and mechanical behaviors of biomolecular assemblies is vital to the rational design and realization of artificial molecular architectures with biologically relevant functionality. Here, we revealed DNA-modulated and mechanoresponsive excitonic couplings between organic chromophores and verified strong correlations between the excitonic chiroptical responses and the conformational and mechanical states of DNA self-assemblies irrespective of fluorescence background interference. Besides, the excitonic chiroptical effect allowed sensitive monitoring of DNA self-assembled nanostructures due to small molecule bindings or DNA strand displacement reactions. Moreover, we developed a new chiroptical reporter, a DNA-templated dimer of an achiral cyanine5 and an intrinsically chiral BODIPY, that exhibited unique multiple-split spectral line shape of exciton-coupled circular dichroism, largely separated response wavelengths, and enhanced anisotropy dissymmetry factor (g-factor). These results shed light on a promising chiroptical spectroscopic tool for studying biomolecular recognition and binding, conformation dynamics, and soft mechanics in general.
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